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Article Title

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Discovery of SOAT2 inhibitors from synthetic small molecules.

Kitasato University

Synthesis and evaluation of novel opioid ligands with a C-homomorphinan skeleton.

Kitasato University

Identification of Novel D-Aspartate Oxidase Inhibitors by in Silico Screening and Their Functional and Structural Characterization in Vitro.

Kitasato University

Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists.

Kitasato University

Naltrindole derivatives with fluorinated ethyl substituents on the 17-nitrogen asd opioid receptor inverse agonists.

Kitasato University

Design, synthesis, and structure-activity relationship of novel opioid¿ receptor selective agonists:a-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton.

Kitasato University

Synthesis and Pharmacology of a Novel¿ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton.

Kitasato University

Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase.

Kitasato University

Synthesis and biological activity of 5-(4-methoxyphenyl)-oxazole derivatives.

Kitasato University

Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies.

Kitasato University

Novel delta opioid receptor agonists with oxazatricyclodecane structure.

Kitasato University

Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening.

Kitasato University

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 3.

Kitasato University

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 2.

Kitasato University

Synthesis and structure-activity relationship of pyripyropene A derivatives as potent and selective acyl-CoA:cholesterol acyltransferase 2 (ACAT2) inhibitors: part 1.

Kitasato University

Identification of novel D-amino acid oxidase inhibitors by in silico screening and their functional characterization in vitro.

Kitasato University

The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives.

Kitasato University

Comparative inhibitory effects of different compounds on rat oatpl (slc21a1)- and Oatp2 (Slc21a5)-mediated transport.

Kitasato University

Inhibition of transporter-mediated hepatic uptake as a mechanism for drug-drug interaction between cerivastatin and cyclosporin A.

Kitasato University

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet).

Kitasato University

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacologies: part 3, novel propellane derivatives with pentacyclic skeletons.

Kitasato University

Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies.

Kitasato University

Synthesis of quinolinomorphinan derivatives as highly selectived opioid receptor ligands.

Kitasato University

Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies.

Kitasato University

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain.

Kitasato University

Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies.

Kitasato University

Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology: part 1.

Kitasato University

Identification of the three-dimensional pharmacophore of kappa-opioid receptor agonists.

Kitasato University

Drug design and synthesis of a novel kappa opioid receptor agonist with an oxabicyclo[2.2.2]octane skeleton and its pharmacology.

Kitasato University

Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin.

Kitasato University

Design and synthesis of novel delta opioid receptor agonists and their pharmacologies.

Kitasato University

Synthesis of a new opioid ligand having the oxabicyclo[3.2.1]octane skeleton using a new rearrangement reaction.

Kitasato University

Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction.

Kitasato University

Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology.

Kitasato University

Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies.

Kitasato University

Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists.

Kitasato University

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet).

Kitasato University

Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 1: Synthesis of triplet drugs with morphinan skeletons.

Kitasato University

Synthesis of 6,14-epoxymorphinan derivatives and their pharmacologies.

Kitasato University

Design and synthesis of KNT-127, ad-opioid receptor agonist effective by systemic administration.

Kitasato University

Synthesis of pyrrolomorphinan derivatives as kappa opioid agonists.

Kitasato University

NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin.

Kitasato University

Investigation of Beckett-Casy model 2: synthesis of novel 15-16 nornaltrexone derivatives and their pharmacology.

Kitasato University

Investigation of Beckett-Casy model 1: synthesis of novel 16,17-seco-naltrexone derivatives and their pharmacology.

Kitasato University

Aerobic oxidation of indolomorphinan without the 4,5-epoxy bridge and subsequent rearrangement of the oxidation product to spiroindolinonyl-C-normorphinan derivative.

Kitasato University

Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens.

Kitasato University

Argifin; efficient solid phase total synthesis and evaluation of analogues of acyclic peptide.

Kitasato University

Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens.

Kitasato University

Discovery of ? opioid receptor full agonists lacking a basic nitrogen atom and their antidepressant-like effects.

Kitasato University

Inhibition of cholesteryl ester synthesis by polyacetylenes from Atractylodes rhizome.

Kitasato University

Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor.

Kitasato University

Inhibition of neutral lipid synthesis by avarols from a marine sponge.

Kitasato University

The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, ? opioid receptor agonists.

Kitasato University

Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies.

Kitasato University

Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities.

Kitasato University

Pharmacological properties of the potent epileptogenic amino acid dysiherbaine, a novel glutamate receptor agonist isolated from the marine sponge Dysidea herbacea.

Kitasato University